Luca Lianas and Cecilia Mascia, from the Data-intensive Computing Sector at CRS4, have co-authored the article Prognostic utility of the Gleason grading system revisions included in the issue of the European Urology Open Science magazine dedicated to the Annual Congress of the European Urology Association.
The work compares different methodologies for the evaluation of prostate cancer severity through the analysis of histo-pathological digital images, and is the most recent result from the long-standing collaboration between CRS4 and clinical specialists of the Karolinska Institutet, Clinical Epidemiology Division, Dept. of Medicine Solna (Stockholm, Sweden), the Karolinska Institutet and Karolinska University Hospital, Dept. of Molecular Medicine and Surgery (Stockholm, Sweden), Karolinska Institutet and Karolinska University Hospital, Dept. of Urology (Stockholm, Sweden), the St Orsola-Malpighi Teaching Hospital, Pathology Service, Addarii Institute of Oncology, University of Bologna, the University of Turin (Cancer Epidemiology Unit, Dept. of Medical Sciences), the A.O.U. Città della Salute e della Scienza (Turin), the Örebro University, Dept. of Urology (Örebro, Sweden), the CPO-Piemonte, Reference Centre for Epidemiology and Cancer Prevention in Piemonte.
In particular, CRS4 and KI have been collaborating since 2016 in the development of advanced methodologies and innovative tools for the analysis of very high resolution digital pathology images and for the management of clinical data and annotations associated with them. As part of this partnership, CRS4 has extended its Digital Pathology platform – which allows the visualization, management and annotation of digital slide images – specializing it for the clinical domain of prostate cancer and enabling the collection of one of the richest annotated datasets in Europe on this type of pathology. CRS4 and KI are currently participating in the EU H2020 DeepHealthProject, which aims to advance the state of the application of Artificial Intelligence techniques in the clinical field.