PhenoMeNal (Phenome and Metabolome aNalysis) is a comprehensive and standardised e-infrastructure that will support the data processing and analysis pipelines for molecular phenotype data generated by metabolomics applications. PhenoMeNal will provide services enabling computation and analysis to improve the understanding of the causes and mechanisms underlying health, healthy ageing and diseases. CRS4 brings to the consortium new competences in automating and scaling computational data analysis while ensuring reproducibility.