The MOST project aims to create a modular, scalable, open source framework for managing real-time medical teleconsultations. The framework will be based on a set of innovative technologies for real-time telemedicine developed by CRS4 and will provide the core technologies to enable the cluster participants to develop telemedicine applications in various clinical contexts (cardiology, emergency/urgency, emodynamics, etc). The purpose of this project is to share the skills and technologies developed by CRS4 and the “telemedicine District-lab” during the development of the REMOTE project, in order to encourage companies to invest in a high impact sector for regional and extra-regional medical supply chain. The project will focus on reengineering prototypes and tecnologies used in REMOTE project, on their abstraction and generalization for public releasing software modules and specific architectural solutions. The solutions can be used from cluster’s companies as technical core for creating specific medical application based on real-time transmissions and collaborative analysis of audio/video stream generated by medical devices. The modules will allow: – real-time recording and remote viewing of video and audio streams captured from heterogeneous medical devices; – the integration of a voice chat for real-time collaboration between multiple specialists or online training sessions; – the customization of a web application for managing patient and clinical data, remote teleconsultation and structured reporting of consultations. The code will be released under an open-source license and published online on one of the mostly used portals for source code sharing (GitHub, Sourceforge, etc..), allowing the growth of a community of users and contributors. The cluster’s companies are going to make the base of the future community.