UOMO Project, or \u201cMan simulator\u201d, aims to bring us closer to a computational system to simulate the effects of a new drug on the human body and to predict drug safety and efficacy. System is based on the integration of different kinds of scientific data: molecular structures; biological activity data, such as bioassay results; pharmacological data describing the effects of molecules on the human body. Data are collected from different sources (e.g. publications, PubChem, US Environmental Protection Agency (EPA)), and are curated to to remove redundancies and assert coherence. The resulting datasets are analyzed with machine learning algorithms to extract important patterns and relations between molecular structrure and activity, from which derive predictive activity models The end result is that for a given new molecule, the system will provide a probable activity profile, and flag high risk situations. The \u201cMan simulator\u201d will be used in virtual screening for new lead compounds and to identify drug candidates that have a high risk of unintended side effects. UOMO project is realized in collaboration with Luca Pani, head of Section of Neuropharmacology of the Institute of Biomedical Technologies, Italian National Research Council, and is funded by the Regione Autonoma della Sardegna.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"gruppo":[],"class_list":["post-19706","projects","type-projects","status-publish","hentry"],"acf":{"title":"Unit\u00e0 Ottimizzate per Modelli Operativi - UOMO","acronym":"UOMO","project_uuid":"6182aa68-b567-1032-95fe-0030485a3848","start_date":"01\/12\/2008","end_date":"31\/07\/2011","funder":"RAS (Delibera 31\/13 del 27\/05\/2008)","partners":"","project_coordinator":[],"proj_website":"http:\/\/migweb.crs4.it\/uomo","project_status":"Completed","team_members":[{"ID":10160,"post_author":"4","post_date":"2025-06-30 17:22:13","post_date_gmt":"2025-06-30 15:22:13","post_content":"Giuliana received a M.Sc. degree in Biology from the University of Cagliari in 2000, with a thesis in pharmacology. Between 2000 and 2002 she worked as a researcher at \"Neuroscienze scarl\", a neuropharmacology research center in Cagliari. In 2003, she took a master's on science dissemination at the \"Il rasoio di Occam\" school of Turin, a post degree professional course. She later proceeded in this field in Rome, working as a scientific journalist trainee at the \"ANSA\" press agency, in the press office of the \"Comitato Telethon Fondazione Onlus\" and for the \"Un Camper per la Scienza\" project of the Adriano Buzzati's Foundation, a project aiming at getting young people interested in sciences. In 2006 she started working at CRS4, dealing maingly with scientific communication and informal science education. She now collaborates with the Educational Technology group and is responsible for organizing students work-linked training activities at CRS4.","post_title":"Giuliana Brunetti","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"giuliana-brunetti","to_ping":"","pinged":"","post_modified":"2026-04-05 20:10:17","post_modified_gmt":"2026-04-05 18:10:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/giuliana-brunetti\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10066,"post_author":"4","post_date":"2025-06-30 17:25:33","post_date_gmt":"2025-06-30 15:25:33","post_content":"Luca Pireddu earned his degree in Computing Science in 2003 from Laurentian University in Sudbury, Canada. Here he also started his research work joining MIRARCO in 2002, where he completed his undergraduate thesis on computational methods to optimize underground mine plans. He later pursued graduate studies at the University of Alberta, Canada, receiving his M.Sc. in Computing Science in 2006 with a thesis on predicting biological pathways by proteome analysis - a project that he continued as a researcher at U. of A. after his studies. After a stint in the private sector, Luca joined CRS4, where he currently works with the Visual and Data-Intensive Computing group. He has coordinated CRS4's participation in several EU, national and regional research projects in the area of novel development and application of data processing, analysis and management techniques to concrete problems in several fields of interest - particularly, bioinformatics, biomedical research and urban computing. He is particularly interested in techniques for facilitating scalability of complex computational scientific workflows, secure and scalable methods to leverage sensitive data collections, and data and workflow re-use through the application of FAIR principles. He represents CRS4 at the Italian nodes of the BBMRI-ERIC and ELIXIR EU Research Infrastructures and at the Data, AI and Robotics (DAIRO) Association (ex BDVA).","post_title":"Luca Pireddu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"luca-pireddu","to_ping":"","pinged":"","post_modified":"2026-04-05 20:13:32","post_modified_gmt":"2026-04-05 18:13:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/luca-pireddu\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\n