{"id":19629,"date":"2025-07-03T18:22:01","date_gmt":"2025-07-03T16:22:01","guid":{"rendered":"https:\/\/www.crs4.it\/projects\/dadicar\/"},"modified":"2026-04-02T12:35:43","modified_gmt":"2026-04-02T10:35:43","slug":"dadicar","status":"publish","type":"projects","link":"https:\/\/www.crs4.it\/en\/projects\/dadicar\/","title":{"rendered":"DADICAR"},"content":{"rendered":"

The objective of the research project is to study the alteration of contractile and metabolic function of the cardiac and smooth muscles in rats with type I diabetes mellitus. Computational and experimental approaches are combined to investigate the relationship between disease and physiological and metabolic dysfunction of the muscles. Muscle electrical stimulation protocols are used to determine the active and passive biomechanical properties of the cardiac and smooth muscle. The parameters of the force-length and force\u2013velocity relationships are determined while the mathematical model of Hodgkin\u2013Huxley is used to quantify the relationship between tension, mechanical energy and velocity of the contractile apparatus in diabetic and control rats. The morphological and bioenergetic characteristics of heart mitochondrial are characterized in diabetic and control rats. Mitochondrial ultrastructural properties are determined with electron microscopy techniques while mitochondrial energetic function is determined using a polarographic system. These observations allow studying the relationship between mitochondrial morphology and function in diabetic rats. The mitochondrial experiments are fundamental to provide the data for computational modeling and analysis. The experimental data are integrated to a computational model of cardiac mitochondrial bioenergetics to study the regulatory mechanisms of the electron transport chain under physiological and pathophysiological conditions.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"gruppo":[],"class_list":["post-19629","projects","type-projects","status-publish","hentry"],"acf":{"title":"Indagine morfo-funzionale sui DAnni indotti dal DIabete sul sistema CARdiovascolare","acronym":"DADICAR","project_uuid":"619907b8-b567-1032-95fe-0030485a3848","start_date":"01\/01\/2014","end_date":"30\/06\/2016","funder":"RAS, L.R. 7\/2007 annualit\u00e0 2012","partners":"\n\n \n \n \n
Nome<\/th>\n Nazione<\/th>\n Ruolo<\/th>\n <\/tr>\n\n
Department of Biomedical Science, Section of Cytomorphology, Cittadella Universitaria di Monserrato, Monserrato (CA), Italy<\/td>\n Italy<\/td>\n Coordinator<\/td>\n <\/tr>\n\n
Department of Biomedical Engineering, Case Western Reserve University Cleveland, Ohio, USA<\/td>\n USA<\/td>\n Partner<\/td>\n <\/tr>\n<\/table>","project_coordinator":[],"proj_website":"","project_status":"Completed","team_members":[{"ID":10055,"post_author":"4","post_date":"2025-06-30 17:25:40","post_date_gmt":"2025-06-30 15:25:40","post_content":"Massimo Pisu is a Senior Researcher and Permanent Project Leader (PPL) in Visual and Data-Intensive Computing (VIDIC) sector of CRS4. He earned with honors his Master Degree in Chemical Engineering from the University of Cagliari (1990) and his PhD from the University of Bologna (1994). Fields of expertise are focused on mathematical modelling and computing simulation of processes at various scale levels for application in chemistry, biology, biotechnology, environment, energy and advanced material sectors. He has been involved in several projects sponsored by the European Community, MIUR, Sardinian Regional Authorities, and by national and international industries. He serves as a reviewer for several international journals in the fields of chemical engineering, biotechnology, and bioengineering. He is coauthor of 3 patents and over 100 publications in international journals and conference proceedings.","post_title":"Massimo Pisu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"massimo-pisu","to_ping":"","pinged":"","post_modified":"2026-04-05 18:13:25","post_modified_gmt":"2026-04-05 16:13:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/massimo-pisu\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nDADICAR - CRS4<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.crs4.it\/en\/projects\/dadicar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DADICAR - CRS4\" \/>\n<meta property=\"og:description\" content=\"The objective of the research project is to study the alteration of contractile and metabolic function of the cardiac and smooth muscles in rats with type I diabetes mellitus. 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