{"id":12702,"date":"2025-07-03T18:18:40","date_gmt":"2025-07-03T16:18:40","guid":{"rendered":"https:\/\/www.crs4.it\/projects\/radar\/"},"modified":"2026-04-02T12:32:50","modified_gmt":"2026-04-02T10:32:50","slug":"radar","status":"publish","type":"projects","link":"https:\/\/www.crs4.it\/en\/projects\/radar\/","title":{"rendered":"RADAR"},"content":{"rendered":"<p>The project aims to conduct histopathological (University of Catania), transmission electron microscopy-TEM (University G. d&#8217;Annunzio Chieti-Pescara), and molecular analyses (CRS4) to study markers of damage and function following RT, both in conventional and FLASH modes. The goals of the project include studying the effect of RT on melanoma and healthy tissues such as skin, adipose tissue, heart, and lung in mice. This will be accomplished by injecting melanoma cells into mice and then exposing them to RT. Current research on FLASH therapy suggests that although there have been some studies on the effects of this treatment on skin tissue, there is still a significant knowledge gap regarding its impact on heart and white adipose tissue (WAT). This lack of information leaves important questions about the safety and efficacy of FLASH therapy unanswered. Considering the vital functions that the heart and WAT perform in the body, it is critical to fill this gap in our knowledge to ensure that FLASH therapy is a safe and efficient treatment option for patients. Therefore, further research is urgently needed to provide a comprehensive analysis of the impact of FLASH therapy on these tissues.<br \/>\nHistopathological, transmission electron microscopy, and molecular analyses to study markers of damage and function will be used to create a database to instruct an artificial intelligence (AI) to identify patterns of damage and function in healthy and tumor tissues, with the goal of improving the efficacy of RT and reducing its side effects.<br \/>\nExpected results include a better understanding of the effect of RT on melanoma and healthy tissues, which could lead to new therapeutic strategies for the treatment of melanoma. In addition, the results could provide valuable information on the response of healthy tissues to FLASH radiotherapy, which could be used to minimize the side effects of therapy.<\/p>\n","protected":false},"featured_media":11007,"template":"","meta":{"_acf_changed":false},"gruppo":[124],"class_list":["post-12702","projects","type-projects","status-publish","has-post-thumbnail","hentry","gruppo-high-performance-and-quantum-computing-biosciences-and-advanced-studies"],"acf":{"title":"Advanced radiotherapies and diagnostics in oncology","acronym":"RADAR","project_uuid":"192c68c4-8a3c-11ef-a6ce-005056a5f278","start_date":"01\/10\/2024","end_date":"31\/08\/2025","funder":"MUR, Bando a Cascata del Partenariato Esteso \u201cTuscany Health Ecosystem (THE)\u201d, finanziato dal PNRR, Missione 4 \u201cIstruzione e ricerca\u201d \u2013 Componente 2 \u201cDalla ricerca all\u2019impresa\u201d \u2013 Investimento 1.3, finanziato dall\u2019Unione europea \u2013 NextGenerationEU Spoke 1 C","partners":"\n<table style=\"width:100%; border-collapse: collapse;\">\n  <tr>\n    <th style=\"border: 1px solid #ddd; padding: 8px; background-color: #f2f2f2;\">Nome<\/th>\n    <th style=\"border: 1px solid #ddd; padding: 8px; background-color: #f2f2f2;\">Nazione<\/th>\n    <th style=\"border: 1px solid #ddd; padding: 8px; background-color: #f2f2f2;\">Ruolo<\/th>\n  <\/tr>\n\n  <tr>\n    <td style=\"border: 1px solid #ddd; padding: 8px;\"><a href=\"https:\/\/www.unict.it\" target=\"_blank\">Universit\u00e0 degli Studi di Catania<\/a><\/td>\n    <td style=\"border: 1px solid #ddd; padding: 8px;\">Italy<\/td>\n    <td style=\"border: 1px solid #ddd; padding: 8px;\">Coordinator<\/td>\n  <\/tr>\n\n  <tr>\n    <td style=\"border: 1px solid #ddd; padding: 8px;\"><a href=\"https:\/\/www.unich.it\" target=\"_blank\">Universit\u00e0 degli Studi di Chieti-Pescara<\/a><\/td>\n    <td style=\"border: 1px solid #ddd; padding: 8px;\">Italy<\/td>\n    <td style=\"border: 1px solid #ddd; padding: 8px;\">Partner<\/td>\n  <\/tr>\n<\/table>","team_members":[],"proj_website":"https:\/\/tuscanyhealthecosystem.it ","project_status":"Execution","project_coordinator":[{"ID":10137,"post_author":"4","post_date":"2025-06-30 17:22:02","post_date_gmt":"2025-06-30 15:22:02","post_content":"Riccardo Berutti, responsible of NGS Bioinformatics @CRS4, works since 2009 in the next generation sequencing field. He developed some among the first NGS analysis pipelines and quality control tools. Riccardo started his career in the Sardinian Genome Study stemming from the ProgeNIA project, on which he worked for his PhD thesis. His results were published with the collaboration on the journal Science.  In 2013 he moved to the Helmholtz Center in Munich for his postdoc with Prof. Thomas Meitinger and Dr. Tim Strom and continued at the Institute of Human Genetics (IHG) of the University Hospital of the Technical University of Munich (TUM), where he was head of the Bioinformatics group till December 2023 and so far produced around 60 peer reviewed publications. At the IHG he managed NGS data analysis applications for research and diagnostics. In the clinical field he acquired a strong experience as software developer, in process control, and in quality management, contributing to the ISO15189 certification of the Institute as a diagnostic laboratory, covering laboratory processes and the bioinformatic analyses developed in house. He is responsible of the development of the open source software EVAdb, for the clinical interpretation of the variants from human genomes and exomes and RNAseq. He also manage the development of their associated pipelines and of the EVAdb LIMS. He will continue the development of these open source tools in a collaborative form at CRS4.","post_title":"Riccardo Berutti","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"riccardo-berutti","to_ping":"","pinged":"","post_modified":"2026-04-05 20:10:08","post_modified_gmt":"2026-04-05 18:10:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/riccardo-berutti\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>RADAR - CRS4<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.crs4.it\/en\/projects\/radar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RADAR - CRS4\" \/>\n<meta property=\"og:description\" content=\"The project aims to conduct histopathological (University of Catania), transmission electron microscopy-TEM (University G. d&#8217;Annunzio Chieti-Pescara), and molecular analyses (CRS4) to study markers of damage and function following RT, both in conventional and FLASH modes. 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