The LIFEMap Project “From Pediatric Pathology to Cardiovascular and Neoplastic Diseases in Adults: Genomic Mapping for Personalized Medicine and Prevention” – Trajectory 3 of the Operational Health Plan of the Ministry of Health – aims to identify pathological and sub-pathological conditions in children and\/or predictive genetic profiles associated with an increased risk of serious diseases in adults, taking into account environmental risk factors to develop personalized therapy and prevention plans for both children and adults.
\n\u00a0For this purpose, the following will be undertaken:<\/p>\n
CRS4 will take part in the project with the following activities:<\/p>\n
| Nome<\/th>\n | Nazione<\/th>\n | Ruolo<\/th>\n <\/tr>\n\n |
|---|---|---|
| IRCCS Ospedale Giannina Gaslini<\/a><\/td>\n | Italy<\/td>\n | Coordinator<\/td>\n <\/tr>\n\n |
| IRCCS Ospedale San Raffaele<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| ASL Teramo<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| Universit\u00e0 degli Sudi dell'Aquila<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| Universit\u00e0 degli Studi di Padova<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| Universit\u00e0 degli Studi di Enna Kore<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| Universit\u00e0 Telematica San Raffaele <\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n\n |
| Centro per la Formazione Permanente e l'Aggiornamento del Personale del Servizio Sanitario<\/a><\/td>\n | Italy<\/td>\n | Partner<\/td>\n <\/tr>\n<\/table>","proj_website":"https:\/\/www.thelifemap.it","project_status":"Execution","project_coordinator":[{"ID":10137,"post_author":"4","post_date":"2025-06-30 17:22:02","post_date_gmt":"2025-06-30 15:22:02","post_content":"Riccardo Berutti, responsible of NGS Bioinformatics @CRS4, works since 2009 in the next generation sequencing field. He developed some among the first NGS analysis pipelines and quality control tools. Riccardo started his career in the Sardinian Genome Study stemming from the ProgeNIA project, on which he worked for his PhD thesis. His results were published with the collaboration on the journal Science. In 2013 he moved to the Helmholtz Center in Munich for his postdoc with Prof. Thomas Meitinger and Dr. Tim Strom and continued at the Institute of Human Genetics (IHG) of the University Hospital of the Technical University of Munich (TUM), where he was head of the Bioinformatics group till December 2023 and so far produced around 60 peer reviewed publications. At the IHG he managed NGS data analysis applications for research and diagnostics. In the clinical field he acquired a strong experience as software developer, in process control, and in quality management, contributing to the ISO15189 certification of the Institute as a diagnostic laboratory, covering laboratory processes and the bioinformatic analyses developed in house. He is responsible of the development of the open source software EVAdb, for the clinical interpretation of the variants from human genomes and exomes and RNAseq. He also manage the development of their associated pipelines and of the EVAdb LIMS. He will continue the development of these open source tools in a collaborative form at CRS4.","post_title":"Riccardo Berutti","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"riccardo-berutti","to_ping":"","pinged":"","post_modified":"2026-04-05 16:10:10","post_modified_gmt":"2026-04-05 14:10:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/riccardo-berutti\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"}],"team_members":[{"ID":10233,"post_author":"4","post_date":"2025-06-30 17:23:13","post_date_gmt":"2025-06-30 15:23:13","post_content":"Enrico Gobbetti is the director of Visual and Data-intensive Computing (ViDiC) at the Center for Advanced Studies, Research, and Development in Sardinia (CRS4), Italy. He holds an Engineering degree (1989) and a Ph.D. degree (1993) in Computer Science from the Swiss Federal Institute of Technology in Lausanne (EPFL), as well as Full Professor Habilitations in Computer Science and Information Processing from the Italian Ministry of University and Research. Prior to joining CRS4, he held research and\/or teaching positions at the Swiss Federal Institute of Technology in Lausanne, the University of Maryland Baltimore County (UMBC), Baltimore MD, USA, and the Center of Excellence in Space Data and Information Sciences (NASA\/CESDIS), NASA Goddard Space Flight Center, Greenbelt MD, USA. At CRS4, Enrico develops and manages a research program in visual and data-intensive computing supported through institutional, industrial and government grants, including many national and international projects. His research spans many areas of visual and data-intensive computing and is widely published in major journals and conferences. The primary focus is the study and creation of innovative, intelligent, and scalable solutions for acquiring, creating, processing, distributing, exploring, and analyzing complex and\/or massive datasets derived from simulations or measurements of phenomena, objects, environments, or real-world processes. He regularly serves the scientific community through participation in editorial boards, program committees, working groups and steering boards, as well as through the organization and chairing of conferences. He is a Fellow of Eurographics.","post_title":"Enrico Gobbetti","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"enrico-gobbetti","to_ping":"","pinged":"","post_modified":"2026-04-05 16:11:37","post_modified_gmt":"2026-04-05 14:11:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/enrico-gobbetti\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10152,"post_author":"4","post_date":"2025-06-30 17:22:09","post_date_gmt":"2025-06-30 15:22:09","post_content":"","post_title":"Gavin Brelstaff","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gavin-brelstaff","to_ping":"","pinged":"","post_modified":"2026-04-05 16:10:17","post_modified_gmt":"2026-04-05 14:10:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/gavin-brelstaff\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10226,"post_author":"4","post_date":"2025-06-30 17:23:05","post_date_gmt":"2025-06-30 15:23:05","post_content":"Francesca coordinates the digital health research activities on the Visual and Data-intensive Computing Sector at CRS4 (prev. Research Programs Digital Health\/Healthcare Flows). Her research activity spans the opportunities and problems arising from the application of computer science to medicine, working on interoperability, traceability, telemedicine and modelling of data and processes in the clinical context. In her 20 years of research experience she has cultivated ongoing collaborations with public and private organisations, including research institutions, hospitals and industries operating in the health IT sector, with particular attention to the direct application of research results in clinical practice. She holds a Ph.D. in Innovation Sciences and Technologies from the University of Cagliari and a degree in Biomedical Engineering from the University of Genoa. Her present research interests are mainly focused on the modelling of biomedical data and processes, with a particular attention to interoperability and traceability, also in the perspective of the application of the FAIR Principles. In particular, she is currently working: on an integration profile about specimen tracking (SET profile), with the IHE PaLM Technical committee; on the modelling of genetic data through the openEHR formalism, with openEHR International; and a standard under development about provenance information in the biotechnology domain (Standard ISO 23494, ISO Technical Committee 276), with BBMRI-ERIC, the European research infrastructure for biobanking.","post_title":"Francesca Frexia","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francesca-frexia","to_ping":"","pinged":"","post_modified":"2026-04-05 16:11:28","post_modified_gmt":"2026-04-05 14:11:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/francesca-frexia\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10251,"post_author":"4","post_date":"2025-06-30 17:23:36","post_date_gmt":"2025-06-30 15:23:36","post_content":"Simone Leo holds a five-year degree in Electronic Engineering from the University of Cagliari and a Ph.D. in Biomedical Engineering from the same university. From 2003 to 2006 he has worked in the private sector as a system administrator. Since 2006 he has been working at CRS4 as a software engineer and, from 2008, as a researcher. His research interests are mainly focused on distributed computing models, with an emphasis on their applicability to computational biology.","post_title":"Simone Leo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"simone-leo","to_ping":"","pinged":"","post_modified":"2026-04-05 16:11:59","post_modified_gmt":"2026-04-05 14:11:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/simone-leo\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10257,"post_author":"4","post_date":"2025-06-30 17:23:42","post_date_gmt":"2025-06-30 15:23:42","post_content":"Lidia Leoni is the High Performance and Quantum Computing, Biosciences and Advanced Studies director at the Center for Advanced Studies, Research, and Development in Sardinia (CRS4). She won a study grant from the European Economic Community and successfully attended a three-year course in information sciences and remote sensing. She is responsible for some of the most important CRS4 research and innovation projects. Her experience ranges from the use of large systems, to application development, to the management and maintenance of networks, systems and services for users. As a sector director, she is involved in several CRS4 projects and contributes to helping other researchers in their work. She is responsible for the biosciences and computational infrastructures of the center , for project services and manages the budget for the purchases of the computing center. Before joining CRS4, she worked at the Sardinia Research Consortium (CORISA), Regional Agrometeorological Service for Sardinia (SAR) and was a consultant for various institutions and companies.","post_title":"Lidia Leoni","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lidia-leoni","to_ping":"","pinged":"","post_modified":"2026-04-05 16:12:04","post_modified_gmt":"2026-04-05 14:12:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/lidia-leoni\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10210,"post_author":"4","post_date":"2025-06-30 17:22:45","post_date_gmt":"2025-06-30 15:22:45","post_content":"Giovanni Delussu is a researcher in the \"Digital Health\" area which belongs to the \"Visual and Data-Intensive Computing\" research Program. He holds a Laurea (MSc) degree in Aeronautical Engineering from the \"Politecnico di Torino\" (1993). Afterwards he worked in the Italian Air Force as officer to ground equipment aircraft maintenance. He joined the CRS4 in 1996. He has worked in many different fields: algorithms and codes for mesh generation, sail aerodynamics, boat hydrodynamics, combustion, dynamic structural calculations on artificial heart valves, rocket for Mars exploration (Prof. Rubbia). He worked also in the renewable energy area, specifically on concentrated solar power (CSP) systems. Then he worked on \"Big Data\" problems. Presently he is working on digital healthcare solutions. In 2017 got his PhD in Innovation Sciences and Technologies jointly awarded by University of Cagliari (UNICA), University of Aveiro (UAVR), Portugal, Pushchino State Institute of Life Sciences, (PSILS), Pushchino, Russia and ENIM Ecole Nationale de l'Industrie Minerale, Morocco with a thesis in the field of Biomedical Informatics. Main interests:surfing, tennis","post_title":"Giovanni Delussu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"giovanni-delussu","to_ping":"","pinged":"","post_modified":"2026-04-05 16:11:07","post_modified_gmt":"2026-04-05 14:11:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/giovanni-delussu\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10208,"post_author":"4","post_date":"2025-06-30 17:22:43","post_date_gmt":"2025-06-30 15:22:43","post_content":"Mauro Del Rio received the M.Sc. degree in Electronic Engineering from the University of Cagliari in 2005. In 2006 he joined the Digital Media Applications group at CRS4. Here he took part to the development of tools and applications for managing multimedia files. Since 2013 he has been working with the Digital Health group. He deals with Telemedicine and distributed computing of clinical data.","post_title":"Mauro Del Rio","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mauro-del-rio","to_ping":"","pinged":"","post_modified":"2026-04-05 16:11:05","post_modified_gmt":"2026-04-05 14:11:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/mauro-del-rio\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10066,"post_author":"4","post_date":"2025-06-30 17:25:33","post_date_gmt":"2025-06-30 15:25:33","post_content":"Luca Pireddu earned his degree in Computing Science in 2003 from Laurentian University in Sudbury, Canada. Here he also started his research work joining MIRARCO in 2002, where he completed his undergraduate thesis on computational methods to optimize underground mine plans. He later pursued graduate studies at the University of Alberta, Canada, receiving his M.Sc. in Computing Science in 2006 with a thesis on predicting biological pathways by proteome analysis - a project that he continued as a researcher at U. of A. after his studies. After a stint in the private sector, Luca joined CRS4, where he currently works with the Visual and Data-Intensive Computing group. He has coordinated CRS4's participation in several EU, national and regional research projects in the area of novel development and application of data processing, analysis and management techniques to concrete problems in several fields of interest - particularly, bioinformatics, biomedical research and urban computing. He is particularly interested in techniques for facilitating scalability of complex computational scientific workflows, secure and scalable methods to leverage sensitive data collections, and data and workflow re-use through the application of FAIR principles. He represents CRS4 at the Italian nodes of the BBMRI-ERIC and ELIXIR EU Research Infrastructures and at the Data, AI and Robotics (DAIRO) Association (ex BDVA).","post_title":"Luca Pireddu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"luca-pireddu","to_ping":"","pinged":"","post_modified":"2026-04-05 16:13:49","post_modified_gmt":"2026-04-05 14:13:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/luca-pireddu\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10164,"post_author":"4","post_date":"2025-06-30 17:22:14","post_date_gmt":"2025-06-30 15:22:14","post_content":"Giovanni Busonera received his M.Sc. in Electronic Engineering from the University of Cagliari in 2004 and the Ph.D. in Electronic Engineering and Computer Science from the same University in 2008. Since 2008 he works at CRS4 as a researcher. His research interests concerned mainly virtualization, distributed programming and hardware acceleration for parallel computing by using GPGPU and FPGA devices. Before joining CRS4, he worked in the Microsoft Research Embedded Group in Redmond developing eBug, a software debugging support for the dynamically reconfigurable processor eMIPS. He also worked on the development of a haplotyping algorithm to perform multi-marker genome wide association study (GWAS). Currently his work deals with signal processing and data analysis for biomedical applications and statistical methods for network traffic modeling.","post_title":"Giovanni Busonera","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"giovanni-busonera","to_ping":"","pinged":"","post_modified":"2026-04-05 16:10:25","post_modified_gmt":"2026-04-05 14:10:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/giovanni-busonera\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10285,"post_author":"4","post_date":"2025-06-30 17:24:17","post_date_gmt":"2025-06-30 15:24:17","post_content":"Cecilia Mascia got her master's degree in Biomedical Engineering in 2013 at the Polytechnic of Turin, with a thesis focused on the evaluation of a telemedicine system developed during an internship at the Digital Health group of the CRS4. In 2015 she collaborated with the Department of Mechanical, Chemical and Materials Engineering of the University of Cagliari in a research project on the analysis, modelling and re-engineering of processes related to the drug supply chain in a private hospital. She joined the DH group in 2014, mainly involved in clinical data modelling activities according to international specifications (openEHR, in particular, and HL7 CDA) for EHR interoperability purposes. She is currently working with the BBMRI-ERIC consortium to draft a proposal of a provenance information model for the biotechnology domain (ISO TC 276) and with the OpenEHR consortium for the definition of genomic data models.","post_title":"Cecilia Mascia","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cecilia-mascia","to_ping":"","pinged":"","post_modified":"2026-04-05 16:12:33","post_modified_gmt":"2026-04-05 14:12:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/cecilia-mascia\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10070,"post_author":"4","post_date":"2025-06-30 17:25:30","post_date_gmt":"2025-06-30 15:25:30","post_content":"Graduated in Computer Engineering at Universit\u00e0 \"La Sapienza\" of Rome, since 2014 he works as a technologist at CRS4. Here he deals with the design and implementation of distributed systems for the processing and storage of large volumes of scientific data (Big Data), with a particular focus on the use of micro-service architectures and the automation of their deployment.","post_title":"Marco Enrico Piras","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marco-enrico-piras","to_ping":"","pinged":"","post_modified":"2026-04-05 16:13:46","post_modified_gmt":"2026-04-05 14:13:46","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/marco-enrico-piras\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9959,"post_author":"4","post_date":"2025-06-30 17:26:39","post_date_gmt":"2025-06-30 15:26:39","post_content":"I'm a computer scientist and my areas of expertise are HPC, bigdataprocessing and machine learning, with scalability as a common thread.I have a background on parallel computing and foundational problemsmotivated by HPC, which I investigated during my PhD and during myyears as a PostDoc in Vienna.In the latest years I have worked, at the CRS4 research center, tobuild efficient and scalable bigdata and machine learning workflows. Ihave worked with streams of genomic and industrial data (using ApacheKafka and Flink as tools) and, within the DeepHealth European project,to the classification of gigapixel medical images, using bothTensorflow and the specialized EDDL ML library. In this context I havea built a scalable pipeline to efficiently manage datasets via the useof Apache Spark and Cassandra.","post_title":"Francesco Versaci","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francesco-versaci","to_ping":"","pinged":"","post_modified":"2026-04-05 16:14:56","post_modified_gmt":"2026-04-05 14:14:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/people\/francesco-versaci\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\n |