{"id":10257,"date":"2025-06-30T17:23:42","date_gmt":"2025-06-30T15:23:42","guid":{"rendered":"https:\/\/www.crs4.it\/people\/lidia-leoni\/"},"modified":"2026-04-10T16:11:59","modified_gmt":"2026-04-10T14:11:59","slug":"lidia-leoni","status":"publish","type":"people","link":"https:\/\/www.crs4.it\/en\/people\/lidia-leoni\/","title":{"rendered":"Lidia Leoni"},"content":{"rendered":"

Lidia Leoni is the High Performance and Quantum Computing, Biosciences and Advanced Studies director at the Center for Advanced Studies, Research, and Development in Sardinia (CRS4). She won a study grant from the European Economic Community and successfully attended a three-year course in information sciences and remote sensing. She is responsible for some of the most important CRS4 research and innovation projects. Her experience ranges from the use of large systems, to application development, to the management and maintenance of networks, systems and services for users. As a sector director, she is involved in several CRS4 projects and contributes to helping other researchers in their work. She is responsible for the biosciences and computational infrastructures of the center , for project services and manages the budget for the purchases of the computing center. Before joining CRS4, she worked at the Sardinia Research Consortium (CORISA), Regional Agrometeorological Service for Sardinia (SAR) and was a consultant for various institutions and companies.<\/p>\n","protected":false},"featured_media":6466,"template":"","meta":{"_acf_changed":false},"gruppo":[124],"class_list":["post-10257","people","type-people","status-publish","has-post-thumbnail","hentry","gruppo-high-performance-and-quantum-computing-biosciences-and-advanced-studies"],"acf":{"name":"Lidia","surname":"Leoni","email":"lidia@crs4.it","phone":"+39 070 9250375","user_uuid":"e3be6430-99fc-1032-95fe-0030485a3848","personal_page":"","google_scholar_id":"","position":"Director","microsoft_academic_id":"","project_coordinator":[{"ID":12676,"post_author":"4","post_date":"2025-07-03 18:18:10","post_date_gmt":"2025-07-03 16:18:10","post_content":"The institutional project Quantum Computation and Communication and High Performance Computing, funded by the contribution under art. 9 L.R. 20\/2015, aims to advance the state of the art in HPC and QC simulation applications and to foster the technological transition to hybrid computing (HPC and Quantum Computing) and quantum communication through the development of innovative methods and approaches for the study of complex systems and processes\u00a0at medium and large scales, based on advanced analysis methods, data acquisition techniques, machine learning techniques and artificial intelligence.\n\u00a0\nIn addition, the project aims to improve the efficiency and sustainability of the complex processes and systems under study by making possible, through a significant reduction in computational time, more accurate modeling of physical phenomena and processes, a reduction in experimental costs, and a significant reduction in the environmental impact of the computational systems used.","post_title":"QCC & HPC","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"qcc-hpc","to_ping":"","pinged":"","post_modified":"2026-04-02 12:32:35","post_modified_gmt":"2026-04-02 10:32:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/qcc-hpc\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12680,"post_author":"4","post_date":"2025-07-03 18:18:15","post_date_gmt":"2025-07-03 16:18:15","post_content":"The project is carried out in collaboration with the Spoke 6 (CNR IGM - Istituto di Genetica Molecolare \"Cavalli-Sforza\" Pavia) of the\u00a0National Center for Gene Therapy and Drugs based on RNA Technology and integrates the clinical trial activities identified by the Spoke 6 with the laboratory and bioinformatics expertise present at CRS4.\n\u00a0\nThe experimental approach focuses on Next Generation Sequencing technology and data analysis. The project is divided into 3 Work Packages: - WP1 activities will be aimed at the development of laboratory protocols and bioinformatics pipelines to be able to respond to all the needs of genetic-molecular characterization of the transcriptome and genome; - WP2 involves the validation of the workflow including all protocols and pipelines developed by performing replicate experiments on samples with known results; - WP3 will consist of the application of the workflow on samples that will be sent to the CRS4 NGS platform with a flow of 6 patients per month.\n\u00a0\nProtocols based on NGS technology including structural changes (short read technology) and post-transcriptional chemical modifications (native RNA\/DNA long read technology) of coding and non-coding RNAs will be developed for comprehensive expression profile analysis.\n\u00a0\nGenome sequencing will provide useful information to elucidate the origins, genetic and epigenetic, of neoplastic transformation of cells. The data produced will be uploaded to an analysis and sharing platform called EvaDB.","post_title":"SPOKE 6 RNA DRUG DEVELOPMENT","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"spoke-6-rna-drug-development","to_ping":"","pinged":"","post_modified":"2026-04-02 12:32:39","post_modified_gmt":"2026-04-02 10:32:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/spoke-6-rna-drug-development\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12704,"post_author":"4","post_date":"2025-07-03 18:18:42","post_date_gmt":"2025-07-03 16:18:42","post_content":"The City of Cagliari has long been engaged in a journey to redefine its digital, integrated and coordinated strategy to address territorial challenges on smart, inclusive and sustainable growth in urban areas. As part of the adoption of the Smart City paradigm, the city has a strong interest in the themes of sustainable mobility, environmental sensing, smart energy management and tourism<\/strong>, themes in which the city has long invested in synergy with companies operating in the area.\u00a0 This investment has materialized over time with the provision of test scenarios within the municipal territory for the implementation of various research and development projects: Joint Innovation Center - JIC; National\u00a0Center\u00a0MOST; Metropolitan Digital Fabric - TDM; Cagliari2020; Cagliari Port 2020; Netergit; Smart Beach; Smart Parking; Smart Traffic; Cagliari Smart City.\n\u00a0\nThere is no doubt that an investment on new digital technologies requires continuous efforts to keep up with the fast pace of technological evolution associated with innovative solutions for cellular communications (5G\/6G) and enabling technologies, including AI, blockchain, quantum computing and IoT. Such investments can hardly be supported by SMEs alone, and this project represents an important effort in favor of the entrepreneurial fabric of the city of Cagliari.\nIn line with this goal, the project intends to provide a physical space and the necessary resources to develop business ideas, experiment with new technologies and transfer the knowledge gained toward SMEs, startups and innovative companies that can particularly benefit from digital transformations. Cagliari \"House of Technology,\" henceforth called Cagliari Digital Lab (CDL)<\/strong>, will therefore be able to fully graft itself into the ongoing activities for the development of new Smart City services envisaged in the METRO National Operational Program by expanding its scope, areas of intervention and sources of funding for experimentation in 5G and for the development and testing of innovative urban services in various sectors.\n\u00a0\nThe Cagliari Digital Lab will be based in Body B of the Bastion of San Remy, in Piazza Costituzione in the historic center of Cagliari, recently restored and used exclusively for the activities envisaged in the project.\u00a0\u00a0The physical space will be set up with workstations, prototyping area, areas for workshops and seminars as well as for carrying out communication, dissemination and animation activities.\nThe lab will be set up with:\n