{"id":10070,"date":"2025-06-30T17:25:30","date_gmt":"2025-06-30T15:25:30","guid":{"rendered":"https:\/\/www.crs4.it\/people\/marco-enrico-piras\/"},"modified":"2026-04-07T14:13:40","modified_gmt":"2026-04-07T12:13:40","slug":"marco-enrico-piras","status":"publish","type":"people","link":"https:\/\/www.crs4.it\/en\/people\/marco-enrico-piras\/","title":{"rendered":"Marco Enrico Piras"},"content":{"rendered":"<p>Graduated in Computer Engineering at Universit\u00e0 &#8220;La Sapienza&#8221; of Rome, since 2014 he works as a technologist at CRS4. Here he deals with the design and implementation of distributed systems for the processing and storage of large volumes of scientific data (Big Data), with a particular focus on the use of micro-service architectures and the automation of their deployment.<\/p>\n","protected":false},"featured_media":12762,"template":"","meta":{"_acf_changed":false},"gruppo":[123],"class_list":["post-10070","people","type-people","status-publish","has-post-thumbnail","hentry","gruppo-data-intensive-computing-en"],"acf":{"name":"Marco Enrico","surname":"Piras","email":"marcoenrico.piras@crs4.it","phone":"","user_uuid":"e3c4517e-99fc-1032-95fe-0030485a3848","personal_page":"","google_scholar_id":"","position":"Technologist","project_coordinator":"","microsoft_academic_id":"","team_members":[{"ID":12560,"post_author":"4","post_date":"2025-07-03 18:17:42","post_date_gmt":"2025-07-03 16:17:42","post_content":"H2UB is intended to be a Life Science infrastructure aimed at fostering new drug development through a network of laboratories capable of providing basic, translational and preclinical research support using cutting-edge technologies.\nGovernance of the Hub will be centralized and will provide support in regulatory, ethics and management, as well as organizational and dissemination.   Expertise will be articulated in thematic platforms that will include:\n<ul>\n<li>basic research (biobanks of iPS and organoids as models of pathology; identification of specific molecular targets; fabrication of bio-electronic systems for drug evaluation);\u00a0<\/li>\n<li>pre-clinical research (animal models, identification and validation of disease biomarkers through computational data analysis, pharmacodynamics);<\/li>\n<li>new drug development (manufacturing, safety monitoring, specificity and formulation);<\/li>\n<li>clinical consulting.\u00a0<\/li>\n<\/ul>\nH2UB meets the need to manage and develop research infrastructure of high complexity. Its value is measured not only in the list of resources and services made available but also as a space where researchers can be stimulated to improve the way they do research by providing expertise, technology, and managerial support.\n\u00a0\nCRS4 will contribute to the:\n<ul>\n<li>implementation and validation of innovative technology platforms for Drug Screening through the definition of genomic and epigenomic targets to be evaluated and the validation of results using genomic techniques;<\/li>\n<li>study, development and implementation of flexible and scalable tools for computational pathology;<\/li>\n<li>developing of molecular modeling tools, to be implemented in the computing platform, with reference to the druggability of molecules and potential drugs on specific therapeutic targets;<\/li>\n<li>organization of training activities and schools on molecular modeling and metabolomics.<\/li>\n<\/ul>","post_title":"H2UB","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"h2ub","to_ping":"","pinged":"","post_modified":"2026-04-02 12:31:59","post_modified_gmt":"2026-04-02 10:31:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/h2ub\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12561,"post_author":"4","post_date":"2025-07-03 18:17:44","post_date_gmt":"2025-07-03 16:17:44","post_content":"The LIFEMap Project \"From Pediatric Pathology to Cardiovascular and Neoplastic Diseases in Adults: Genomic Mapping for Personalized Medicine and Prevention\" - Trajectory 3 of the Operational Health Plan of the Ministry of Health - aims to identify pathological and sub-pathological conditions in children and\/or predictive genetic profiles associated with an increased risk of serious diseases in adults, taking into account environmental risk factors to develop personalized therapy and prevention plans for both children and adults.\n\u00a0For this purpose, the following will be undertaken:\n\n<li>Development of a federated database for the integration of genomic and phenotypic data;<\/li>\n<li>Utilization of a dataset (\u22655,000 patients) comprising clinical, genomic, and environmental (lifestyle) data for AI analysis;<\/li>\n<li>Recruitment of new cases, both pediatric and adult (5,000 patients), with detailed clinical characterization;<\/li>\n<li>Development of a scalable and reusable platform for the analysis and sharing of new data (1,400 WGS, 3,600 SNP);<\/li>\n<li>Identification of a series of genetic variants and profiles associated with the risk of developing obesity, chronic inflammatory diseases, pediatric neoplasms, and their complications in adulthood;<\/li>\n<li>Development of an AI analysis framework and application of Deep Learning for Network Medicine;<\/li>\n<li>Implementation of a biobank of samples, potentially reusable beyond the project's completion.<\/li>\n\nCRS4 will take part in the project with the following activities:\n<ul>\n<li>Whole Genome Sequencing on approximately 1,000 samples;<\/li>\n<li>development of scalable and reusable platforms for WGS data analysis for variant identification;<\/li>\n<li>genomic data modeling, standardization and sharing in international reference platforms;<\/li>\n<li>application of scalable platforms for WGS analysis and data sharing;<\/li>\n<li>scientific dissemination.<\/li>\n<\/ul>\n<ul>\n<\/ul>","post_title":"LIFEMAP","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lifemap","to_ping":"","pinged":"","post_modified":"2026-04-02 12:32:01","post_modified_gmt":"2026-04-02 10:32:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/lifemap\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12678,"post_author":"4","post_date":"2025-07-03 18:18:12","post_date_gmt":"2025-07-03 16:18:12","post_content":"The purpose of the ToPMa Project is the creation of tools and methodologies that enable the transfer of individual health data to personal repository systems made available to the citizens, in a continuous and automatic manner, from institutional and non-institutional sources, based on what is specified in an informed consent defined prior to the start of data transfer and dynamically modifiable at any time by the individuals.","post_title":"ToPMa","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"topma","to_ping":"","pinged":"","post_modified":"2026-04-02 12:32:14","post_modified_gmt":"2026-04-02 10:32:14","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/topma\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12688,"post_author":"4","post_date":"2025-07-03 18:18:25","post_date_gmt":"2025-07-03 16:18:25","post_content":"The aim of this training course is to consolidate skills useful for tackling the transition of the BBMRI-ERIC biobanks geared to the cornerstones of the FAIR Principles (Findability-Accessibility-Interoperability-Reusability), particularly with regard to the data held and the processes that generate or aggregate them.<br\/>The programme starts by reinforcing the participants' skills in system and biomedical data management and explores the topics of interoperability (technical and semantic), scalable and reproducible computing and the application of the FAIR Principles in biomedical research contexts.<br\/>The course is organised in theoretical lectures accompanied by practical sessions (topic-specific or as part of the realisation of a final project).","post_title":"BBMRI TRAINING","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bbmri-training","to_ping":"","pinged":"","post_modified":"2026-04-02 12:32:43","post_modified_gmt":"2026-04-02 10:32:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/bbmri-training\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14761,"post_author":"4","post_date":"2025-07-03 18:19:29","post_date_gmt":"2025-07-03 16:19:29","post_content":"The 13 <a>ESFRI<\/a> research infrastructures in the <a>Health and Food domain<\/a> in March 2019 started the EOSC-Life project to create an open collaborative  digital space for life science in the European Open Science Cloud  (EOSC).\nLife science research directly addresses key societal challenges and  drives the bio-economy. To keep European Life Science at the forefront  of global advances and to deepen our understanding of life and disease,  the data, digital services and advanced facilities vital for life  science research must be findable, accessible, interoperable, reusable  (FAIR) across scientific disciplines and national boundaries. FAIR data  and services improves reproducibility of biomedical research, drives new  scientific discoveries and enables any researcher in Europe and across  the world to access and use them.\nIn EOSC-Life the research infrastructures will publish data from  facilities and data resources in the EOSC and link these FAIR databases  to open and reusable tools and workflows accessible to users via  Europe\u2019s national and international life-science clouds. EOSC-Life will  also connect users across Europe to a single login authentication and  resource authorisation system and develop data policies needed to  preserve and deepen the trust given by research participants and  patients volunteering their data and samples.\nEOSC-Life project is coordinated by ELIXIR, the ESFRI Research  Infrastructure for biological data. The consortium of 13 Research  Infrastructures cover all aspects of life science research and all life  science domains.\n<strong>Some Figures<\/strong><br\/> EOSC-Life brings together the 13 research infrastructures in the Health and Food domain of the ESFRI Roadmap\u00a0<br\/><strong>Project Duration:\u00a0<\/strong>48 mesi<br\/><strong>Partners: <\/strong>46 Partners, 17 Linked Third parties, 12 Third parties<br\/><strong>Resources:\u00a0<\/strong>23.7 M\u20ac, 11 Work Packages, 34 Deliverables","post_title":"EOSC Life","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"eosc-life","to_ping":"","pinged":"","post_modified":"2026-04-02 12:33:25","post_modified_gmt":"2026-04-02 10:33:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/eosc-life\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19615,"post_author":"4","post_date":"2025-07-03 18:21:30","post_date_gmt":"2025-07-03 16:21:30","post_content":"PhenoMeNal (Phenome and Metabolome aNalysis) is a comprehensive and standardised e-infrastructure that will support the data processing and analysis pipelines for molecular phenotype data generated by metabolomics applications. PhenoMeNal will provide services enabling computation and\u00a0 analysis to improve the understanding of the causes and mechanisms\u00a0 underlying health, healthy ageing and diseases. CRS4 brings to the consortium new competences in automating and scaling computational data analysis while ensuring reproducibility.","post_title":"PhenoMeNal (Phenome and Metabolome aNalysis)","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"phenomenal-phenome-and-metabolome-analysis","to_ping":"","pinged":"","post_modified":"2026-04-02 12:35:17","post_modified_gmt":"2026-04-02 10:35:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/phenomenal-phenome-and-metabolome-analysis\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19622,"post_author":"4","post_date":"2025-07-03 18:21:44","post_date_gmt":"2025-07-03 16:21:44","post_content":"In the Project, CRS4 will support the Consotium of the EU Project <strong><a>Cy-TEST<\/a> <\/strong>(2014-1-IT01-KA202-002607) for the realization of an innovative training system for cytology, based on technologies developed during the strategic Project Wellcome Trust <strong><a>Omero<\/a><\/strong> (Model driven data-management). The result will be a web platform for virtual microscopy images -- and bioimages in general -- distribution and e-learning specialized for cytologists. The infrastructure will be based on state-of-the-art opensource software: OMERO for digital pathology image management and MOODLE for the e-learning component.<br\/>","post_title":"CYTEST","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cytest","to_ping":"","pinged":"","post_modified":"2026-04-02 12:35:30","post_modified_gmt":"2026-04-02 10:35:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/cytest\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Marco Enrico Piras - CRS4<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.crs4.it\/en\/people\/marco-enrico-piras\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Marco Enrico Piras - CRS4\" \/>\n<meta property=\"og:description\" content=\"Graduated in Computer Engineering at Universit\u00e0 &#8220;La Sapienza&#8221; of Rome, since 2014 he works as a technologist at CRS4. 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