{"id":10055,"date":"2025-06-30T17:25:40","date_gmt":"2025-06-30T15:25:40","guid":{"rendered":"https:\/\/www.crs4.it\/people\/massimo-pisu\/"},"modified":"2026-04-05T14:13:49","modified_gmt":"2026-04-05T12:13:49","slug":"massimo-pisu","status":"publish","type":"people","link":"https:\/\/www.crs4.it\/en\/people\/massimo-pisu\/","title":{"rendered":"Massimo Pisu"},"content":{"rendered":"<p>Massimo Pisu is a Senior Researcher and Permanent Project Leader (PPL) in Visual and Data-Intensive Computing (VIDIC) sector of CRS4. He earned with honors his Master Degree in Chemical Engineering  from the University of Cagliari (1990) and his PhD from the University of Bologna (1994). Fields of expertise are focused on mathematical modelling and computing simulation of processes at various scale levels for application in chemistry, biology, biotechnology, environment, energy and advanced material sectors. He has been involved in several projects sponsored by the European Community, MIUR, Sardinian Regional Authorities, and by national and international  industries. He serves as a reviewer for several international journals in the fields of chemical engineering, biotechnology, and bioengineering. He is coauthor of 3 patents and over 100 publications in international journals and conference proceedings.<\/p>\n","protected":false},"featured_media":4093,"template":"","meta":{"_acf_changed":false},"gruppo":[123],"class_list":["post-10055","people","type-people","status-publish","has-post-thumbnail","hentry","gruppo-data-intensive-computing-en"],"acf":{"name":"Massimo","surname":"Pisu","email":"massimo@crs4.it","phone":"+070 9250240","user_uuid":"e3be20c4-99fc-1032-95fe-0030485a3848","personal_page":"http:\/\/www.crs4.it\/peopledetails\/52\/massimo-pisu\/","google_scholar_id":"https:\/\/scholar.google.com\/citations?user=Q7-eLOwAAAAJ","position":"Researcher","microsoft_academic_id":"","project_coordinator":[{"ID":12560,"post_author":"4","post_date":"2025-07-03 18:17:42","post_date_gmt":"2025-07-03 16:17:42","post_content":"H2UB is intended to be a Life Science infrastructure aimed at fostering new drug development through a network of laboratories capable of providing basic, translational and preclinical research support using cutting-edge technologies.\nGovernance of the Hub will be centralized and will provide support in regulatory, ethics and management, as well as organizational and dissemination.   Expertise will be articulated in thematic platforms that will include:\n<ul>\n<li>basic research (biobanks of iPS and organoids as models of pathology; identification of specific molecular targets; fabrication of bio-electronic systems for drug evaluation);\u00a0<\/li>\n<li>pre-clinical research (animal models, identification and validation of disease biomarkers through computational data analysis, pharmacodynamics);<\/li>\n<li>new drug development (manufacturing, safety monitoring, specificity and formulation);<\/li>\n<li>clinical consulting.\u00a0<\/li>\n<\/ul>\nH2UB meets the need to manage and develop research infrastructure of high complexity. Its value is measured not only in the list of resources and services made available but also as a space where researchers can be stimulated to improve the way they do research by providing expertise, technology, and managerial support.\n\u00a0\nCRS4 will contribute to the:\n<ul>\n<li>implementation and validation of innovative technology platforms for Drug Screening through the definition of genomic and epigenomic targets to be evaluated and the validation of results using genomic techniques;<\/li>\n<li>study, development and implementation of flexible and scalable tools for computational pathology;<\/li>\n<li>developing of molecular modeling tools, to be implemented in the computing platform, with reference to the druggability of molecules and potential drugs on specific therapeutic targets;<\/li>\n<li>organization of training activities and schools on molecular modeling and metabolomics.<\/li>\n<\/ul>","post_title":"H2UB","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"h2ub","to_ping":"","pinged":"","post_modified":"2026-04-02 12:31:59","post_modified_gmt":"2026-04-02 10:31:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/h2ub\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19673,"post_author":"4","post_date":"2025-07-03 18:23:17","post_date_gmt":"2025-07-03 16:23:17","post_content":"The research project NANOTOXSTAMOD will contribute, significantly, to the development of knowledge in the field of in vitro cells cultivation in the presence of specific substance which can affect their growth and expansion, leading to an inhibitory and\/or toxic effect. The analysis of the latter one is particularly useful in testing drugs for their development and design. The computational approach, combined with the experimental one, permits, at relatively low cost, the massive screening of drugs. A reliable mathematical model, developed during the present project, will provide a valuable support to reduce testing time and costs","post_title":"NANOTOXSTAMOD","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nanotoxstamod","to_ping":"","pinged":"","post_modified":"2026-04-02 12:37:06","post_modified_gmt":"2026-04-02 10:37:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/nanotoxstamod\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"}],"team_members":[{"ID":16798,"post_author":"4","post_date":"2025-07-03 18:20:13","post_date_gmt":"2025-07-03 16:20:13","post_content":"","post_title":"COMISAR","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"comisar","to_ping":"","pinged":"","post_modified":"2026-04-02 12:34:03","post_modified_gmt":"2026-04-02 10:34:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/comisar\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19787,"post_author":"4","post_date":"2025-07-03 18:20:28","post_date_gmt":"2025-07-03 16:20:28","post_content":"Innovation of products based on nanoparticles through waste from fish production, optimization of the process of surface treatment and preparation of the mixture and study of toxicity on humans and the environment.<br\/><br\/>The research project aims to recover waste products from the agro-industrial chain, and enhance them through transformation into raw material for the production of innovative nanoparticle mixtures, able to improve adhesion to surfaces of a heterogeneous nature, tolerance to variations in environmental parameters and protection of the treated surface. In detail, it is intended to extract compounds derived from adhesion proteins from waste from the fish chain, to grind them and add them to mixtures of commercial nanoparticles. The mixtures thus obtained will then be functionally evaluated, experimentally characterized and simulated using the computer in order to assess their toxicity. At the end of the project, the mixture with the best characteristics will be selected, which will be the prototype for further future developments.","post_title":"Sa.No","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sa-no","to_ping":"","pinged":"","post_modified":"2026-04-02 12:34:17","post_modified_gmt":"2026-04-02 10:34:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/sa-no\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19629,"post_author":"4","post_date":"2025-07-03 18:22:01","post_date_gmt":"2025-07-03 16:22:01","post_content":"The objective of the research project is to study the alteration of contractile and metabolic function of the cardiac and smooth muscles in rats with type I diabetes mellitus. Computational and experimental approaches are combined to investigate the relationship between disease and physiological and metabolic dysfunction of the muscles. Muscle electrical stimulation protocols are used to determine the active and passive biomechanical properties of the cardiac and smooth muscle. The parameters of the force-length and force\u2013velocity relationships are determined while the mathematical model of Hodgkin\u2013Huxley is used to quantify the relationship between tension, mechanical energy and velocity of the contractile apparatus in diabetic and control rats. The morphological and bioenergetic characteristics of heart mitochondrial are characterized in diabetic and control rats. Mitochondrial ultrastructural properties are determined with electron microscopy techniques while mitochondrial energetic function is determined using a polarographic system. These observations allow studying the relationship between mitochondrial morphology and function in diabetic rats. The mitochondrial experiments are fundamental to provide the data for computational modeling and analysis. The experimental data are integrated to a computational model of cardiac mitochondrial bioenergetics to study the regulatory mechanisms of the electron transport chain under physiological and pathophysiological conditions.","post_title":"DADICAR","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dadicar","to_ping":"","pinged":"","post_modified":"2026-04-02 12:35:43","post_modified_gmt":"2026-04-02 10:35:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/dadicar\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19710,"post_author":"4","post_date":"2025-07-03 18:24:29","post_date_gmt":"2025-07-03 16:24:29","post_content":"The challenge is to develop, also by means of self-propagating chemical reactions under microgravity conditions, like those ones on the Moon new processes for manned space exploration. The objective: to allow manned space missions to extract and to utilize in-situ resources like oxygen and nitrogen necessary for human survival without being equipped with huge amount of supplies and to utilize specific tools to repair lunar and\/or martian platforms also using in-situ materials, without going necessarily back to the Earth.\nThis is the brief identity card of COSMIC (Combustion Synthesis under Microgravity Conditions) project which will be developed at the University of Cagliari, Dipartimento di Ingegneria Chimica e Materiali, where the project coordinator Prof. Giacomo Cao works. The involved partners are: Dipartimento Energia e Trasporti of CNR, Centro di Ricerca Sviluppo e Studi Superiori in Sardegna (CRS4), Istituto Tecnico Industriale \u2018Enrico Fermi\u2019 (Cosenza), COREM srl, Esplora srl and SpaceLand srl. COSMIC, the first Italian project sponsored by the Italian Space Agency \u00a0(ASI) in the framework of the manned space exploration, will develop research activities and technological innovation not only for the manned exploration, but particularly for the technology transfer in favour of several applications to be performed on the Earth, in the framework of which suitable spin-offs are foreseen through the propagation of the financial support allowed at this stage. The research activity will be also dedicated to the evaluation of both the physico-chemical and structural characteristics of the products obtained by means of the developed processes, and specific parameters such as initial mixture composition or reactants particle size. One of the objectives is to verify if the suppression of sedimentation and buoyancy phenomena under microgravity conditions will allow the development of new processes whose final products are characterized by microstructural, mechanical and thermo-chemical properties unique or superior with respect to terrestrial analogues. In brief to understand how and how much processes and related products are dissimilar under microgravity conditions. Suitable parabolic flights will allow one to test the proposed processes under simulated lunar gravity.","post_title":"COSMIC","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cosmic","to_ping":"","pinged":"","post_modified":"2026-04-02 12:37:55","post_modified_gmt":"2026-04-02 10:37:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.crs4.it\/projects\/cosmic\/","menu_order":0,"post_type":"projects","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Massimo Pisu - CRS4<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.crs4.it\/en\/people\/massimo-pisu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Massimo Pisu - CRS4\" \/>\n<meta property=\"og:description\" content=\"Massimo Pisu is a Senior Researcher and Permanent Project Leader (PPL) in Visual and Data-Intensive Computing (VIDIC) sector of CRS4. He earned with honors his Master Degree in Chemical Engineering from the University of Cagliari (1990) and his PhD from the University of Bologna (1994). 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